哺乳动物进化性数字损失的模式和后模式模式
Kimberly L Cooper1, Karen E Sears2, Aysu Uygur3
11] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA. [3].
Nature
|July 4, 2014
概括
哺乳动物的数字缩小通过多种不同的发育途径进化. 一些物种使用细胞死亡来雕刻数字,而另一些物种则改变早期四肢的图案,揭示了进化的可塑性.
科学领域:
- 发育生物学是发展生物学.
- 进化生物学是进化的生物学.
- 比较解剖学的比较解剖学.
背景情况:
- 数字缩小是 cursorial 哺乳动物的一个常见的进化适应.
- 导致数字丢失的发育机制尚未得到充分理解.
研究的目的:
- 调查各种哺乳动物物种的指甲损失背后的发育机制.
- 了解肢体发育中的进化可塑性.
主要方法:
- 对杰博阿,马,驼和猪肢体发育的比较分析.
- 检查细胞死亡和基因表达模式在代过程中.
主要成果:
- 数字的损失可以发生在早期的四肢模式或晚期的体发育阶段.
- 杰博亚,马和驼表现出显著的细胞死亡.
- 猪数字损失涉及早期模式变化,包括Ptch1下调,而不会增加细胞死亡.
结论:
- 脊椎动物四肢的进化在发育机制中表现出了显著的可塑性.
- 形态的融合,特别是在类动物中,涉及到不同的进化策略.
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