Ptch1对SHH的减弱感知是牛肢体进化的基础
Javier Lopez-Rios1, Amandine Duchesne2, Dario Speziale3
11] Developmental Genetics, Department Biomedicine, University of Basel, CH-4058 Basel, Switzerland [2].
Nature
|July 4, 2014
概括
基因调节的进化变化解释了牛和相关物种在肢体发育过程中如何失去数字不对称. 这项研究的重点是Ptch1基因和Sonic hedgehog在牛胚胎中的信号传递.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 四足动物的四肢形态表现出从祖先的五爪形状表现出广泛的进化多样化.
- 像牛这样的平脚类动物 (artiodactyls) 显示四肢适应运行,其特点是减少的远部骨元素和对称的,延长的中间数字.
研究的目的:
- 调查在牛肢体发育过程中数字不对称性丧失背后的分子机制.
- 为了比较牛胚胎与小鼠肢体发育期间的基因表达模式.
主要方法:
- 在肢体发育过程中对牛胚胎的分析.
- 对基因表达的检查,特别关注Ptch1基因及其调节元件.
- 用小鼠四肢发育模型进行比较分析.
主要成果:
- 与小鼠相比,在牛的四肢发育过程中,极化基因表达逐渐消失.
- 转录Ptch1基因的上调调节在牛肢介质中被破坏.
- 一个Ptch1 cis-regulatory模块的进化变化阻止了对Sonic hedgehog (SHH) 信号的适当响应.
结论:
- 提供了关于牛肢体芽的数字不对称性损失的分子解释.
- 在Ptch1 cis-regulatory景观的修改涉及到形动物肢体的进化多样化.
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