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崇高的微质:中央神经系统的守护者的角色不断扩大

Michael W Salter¹, Simon Beggs²

¹Neurosciences & Mental Health Program, Hospital for Sick Children, University of Toronto Centre for the Study of Pain, Toronto, Ontario M5G 1X8, Canada; Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario M5G 1X8, Canada; Department of Physiology, Faculty of Dentistry, University of Toronto Centre for the Study of Pain, Toronto, Ontario M5G 1X8, Canada.

|July 5, 2014

概括

中枢神经系统 (CNS) 的免疫细胞 - - 微质细胞 - - 积极塑造大脑结构和功能,不仅在疾病期间,而且在整个生命中发挥作用. 这项研究探讨了它们在神经炎症之外的关键作用.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

传统上,微质被认为主要参与中枢神经系统 (CNS) 对损伤和疾病的反应.
新出现的证据表明,微质细胞在健康的中枢神经系统中起着重要的生理作用.

研究的目的:

挑战以疾病为中心的微质视角.
为超越神经炎症的微质功能提出一个概念框架.
突出显示微质体的生理和病理作用背后的信号机制.

主要方法:

文献综述和最近发现的综合.
基于现有证据的概念框架的开发.
微质信号和通信通路的分析.

主要成果:

微质细胞积极塑造中枢神经系统结构,并完善神经元电路.
微质细胞有助于神经可塑性和网络连接在健康的中枢神经系统.
这些功能从发育到成熟都存在.

结论:

微质是正常中枢神经系统生理学的组成部分,而不仅仅是病理.
更广泛地了解微质的作用是必不可少的.
微质信号通路对于中枢神经系统的健康和疾病都至关重要.

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