相关实验视频

Updated: Mar 30, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

维生素D促进了血管再生

Michael Sze Ka Wong¹, Matthias S Leisegang¹, Christoph Kruse¹

¹From the Institute for Cardiovascular Physiology (M.S.K.W., M.S.L., C.K., J.V., C.S., K.S., R.P.B.), Institute of Biochemistry I (N.D., A.W., B.B.), Institute for Biostatistics and Mathematical Modeling (E.H.), Institute of Pharmaceutical Chemistry/Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (D.S.), Goethe University, Frankfurt, Germany; German Center for Cardiovascular Research, Partner Site RheinMain, Frankfurt, Germany (M.S.L., C.K., C.S., E.H., S.O., K.S., R.P.B.); Cardiovascular Division, King's College London British Heart Foundation Center of Excellence, London, United Kingdom (A.M.S.); Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.O.); Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium (G.C.); and Department of Endocrinology and Diabetes, Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany (K.B.).

|July 13, 2014

概括

维生素D3 (1,25-VitD3) 通过增加血管性髓状细胞,促进血管再生. 这种维生素D代谢物通过诱导SDF1来增强受伤后的愈合,为血管修复提供了一种新的治疗方法.

科学领域:

心血管生物学心血管生物学
内分泌学在内分泌学.
再生医学是一种再生医学.

背景情况:

维生素D缺乏是常见的,并与炎症和心血管疾病有关.
1,25-二氧维生素D3 (1,25-VitD3) 在心血管系统中的作用受到争议,具有潜在的危害 (化) 和益处 (抗炎症).
形成了一个假设,即1,25-VitD3有助于损伤后的血管修复.

研究的目的:

研究1,25-VitD3在受伤后促进血管再生方面的潜力.
阐明 1,25-VitD3 影响血管愈合的机制.

主要方法:

在健康志愿者中补充维生素D3和在小鼠中补充1,25-VitD3的血管损伤模型 (动脉,大腿动脉绑定).
评估血管性髓状细胞,再内皮质化和血管生成.
调查CXCR4,SDF1和缺氧诱导因子1-α (HIF-1α) 信号通路的作用.
利用特定细胞类型中维生素D受体的条件淘汰模型.

主要成果:

维生素D3补充剂增加了人类循环中的血管性髓状细胞.
1,25-VitD3在小鼠模型中增加了血管性髓状细胞,并促进了再内化,包括糖尿病小鼠的血管生成受损.
亲再生效应取决于SDF1/CXCR4信号传递和骨髓细胞中的维生素D受体表达.
在机械上,1,25-VitD3调节了HIF-1α,这反过来又促进了SDF1的表达.

结论:

维生素D3,通过1,25-VitD3,增强血管修复和再生.
该机制涉及通过1,25-VitD3诱导SDF1在骨髓细胞中,由HIF-1α介导.
这突出了维生素D3作为促进血管愈合的潜在治疗策略.

关键词:

血管新生是因为血管新生.它们的内皮质 (endothelium).重新形成的endothelialization是什么意思复兴再生是一种再生方式.维生素D是维生素D的重要组成部分.

更多相关视频

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 24, 2014

相关概念视频

Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...

Connective Tissue Cell Types

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...