通过A20对NLRP3炎症酶的负调节可以防止关节炎

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Updated: Apr 26, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

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Lieselotte Vande Walle1,2, Nina Van Opdenbosch1,2, Peggy Jacques3

  • 1Department of Medical Protein Research, VIB, Ghent, B-9000, Belgium.

Nature
|July 22, 2014
PubMed
概括

在新的小鼠模型中,类风湿性关节炎的病理取决于Nlrp3炎症酶. 在骨髓细胞中删除A20基因会引发关节炎,突出显示A20是该疾病中炎症酶激活的调节者.

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