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rhesus的I型干扰素反应可以预防SIV感染,并减缓疾病的进展

Netanya G Sandler¹, Steven E Bosinger², Jacob D Estes³

¹1] Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas 77555, USA.

|July 22, 2014

概括

I型干扰素 (IFN-I) 在艾滋病毒感染中具有双重作用. 在感染SIV的中操纵IFN-I信号表明,时间对疾病进展和治疗结果至关重要.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
传染性疾病传染性疾病

背景情况:

艾滋病毒感染的炎症预测疾病的进展和死亡率.
I型干扰素 (IFN-I) 起着复杂的作用,有助于天生的免疫力,但也促进HIV复制和损害免疫恢复.
了解IFN-I信号对于开发有效的HIV疗法至关重要.

研究的目的:

为了研究操纵IFN-I信号对 rhesus猿免疫缺陷病毒 (SIV) 感染的影响.
为了确定IFN-I受体阻塞和IFN-α2a在急性SIV感染期间的后果.

主要方法:

rhesus 曾经受到SIV传播和急性感染.
使用了两种体内干预措施:阻断IFN-I受体和给予IFN-α2a.
监测了抗病毒基因表达,SIV储存量大小,CD4 T细胞计数和T细胞激活.

主要成果:

IFN-I受体阻断降低了抗病毒基因表达,增加了SIV储量,并加速了CD4 T细胞枯竭.
最初的IFN-α2a给药促进了抗病毒反应,并预防了全身感染.
持续的IFN-α2a治疗导致脱敏,减少抗病毒基因表达,并恶化疾病的进展.

结论:

IFN-I信号操纵的时间对SIV疾病的过程产生了深远的影响.
虽然IFN-I具有抗病毒作用,但其持续的信号传递可能是有害的.
针对艾滋病毒感染的IFN-I的治疗策略需要仔细考虑,因为体内不可预测的后果.

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