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Updated: Apr 26, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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与thalidomide复合的DDB1-CRBN E3泛素结合酶的结构

Eric S Fischer1, Kerstin Böhm1, John R Lydeard2

  • 11] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland [2] University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland.

Nature
|July 22, 2014
PubMed
概括

免疫调节药物 (IMiDs) 尽管过去具有致性,但现在通过向CRL4 (CRBN) E3无素连酶来治疗癌症. 新的结构揭示了IMiD如何结合CRBN,阻断某些基质,同时促进其他向蛋白质降解.

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