西藏人高度适应是由于丹尼索瓦类DNA的内进而引起的
Emilia Huerta-Sánchez1, Xin Jin2, Asan3
11] BGI-Shenzhen, Shenzhen 518083, China [2] Department of Integrative Biology, University of California, Berkeley, California 94720 USA [3] School of Natural Sciences, University of California, Merced, California 95343 USA [4].
Nature
|July 22, 2014
概括
现代人类通过Denisovans的基因侵入来适应高海拔地区. EPAS1基因显示出这种添加物的证据,为在极端环境中生存提供了关键的遗传变异.
科学领域:
- 人类进化人类的进化.
- 古遗传学 古遗传学
- 人口遗传学 人口遗传学
背景情况:
- 从非洲迁移的现代人类面临着各种环境压力,包括极端温度,病原体和高海拔地区.
- 当地适应是通过自然选择产生的,西藏适应高海拔低氧是其中一个关键例子.
- 参与缺氧途径的EPAS1基因在藏人中表现出强烈的阳性选择,并与血红蛋白水平有关.
研究的目的:
- 研究藏人适应高海拔环境的遗传基础.
- 为了确定在西藏人中选择的EPAS1单元型的起源.
- 探索古老人种混合物在人类适应中的作用.
主要方法:
- 在藏族和汉族人群中重新测序EPAS1基因区域.
- 在全球人口中分析类型结构和频率.
- 比较西藏单元类型与丹尼索瓦人的遗传数据.
主要成果:
- 西藏人的EPAS1基因表现出一种不寻常的单元型结构.
- 这种结构的最佳解释是来自丹尼索瓦人或相关人类的DNA内进.
- 在丹尼索瓦人和西藏人中存在选择的单元型,但在汉族中很少见.
结论:
- 与丹尼索瓦人混合,为人类适应高海拔环境提供了必要的遗传变异.
- EPAS1基因入侵突出了古老人类对现代人类进化的贡献.
- 这项研究表明,与其他人类物种的交配促进了适应新生态的过程.
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