对于静脉性腿部的局部和全身抗菌疗法
Susan O'Meara1, Rachel Richardson2, Benjamin A Lipsky3
1School of Healthcare, Baines Wing, University of Leeds, England.
JAMA
|July 25, 2014
概括
系统性抗生素对静脉腿愈合没有明显的益处. 然而,与这些慢性伤口的标准伤口护理相比,局部的 cadexomer 可能会改善愈合.
科学领域:
- 血管医学 血管医学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 静脉腿 (VLU) 是一种慢性,使人衰弱的伤口.
- 对于VLU管理,经常考虑使用抗菌药物治疗.
- 关于抗菌剂在VLU治疗中的有效性的证据有限.
研究的目的:
- 评估局部或全身抗菌剂在静脉腿部治愈方面的有效性.
- 为了比较抗微生物治疗与常规护理或替代抗微生物疗法.
主要方法:
- 临床试验的系统审查和元分析.
- 包括比较抗微生物药物 (局部或全身) 与通常护理或其他抗微生物药物的研究.
- 评估愈作为主要结果.
主要成果:
- 从不足的研究中汇集的数据无法确定或反驳系统性抗生素和改善VLU愈合之间的联系.
- 与常规护理相比,局部 cadexomer 显示出与更好的愈合结果的潜在关联.
- 对其他局部或全身抗微生物药物的证据是不确定的.
结论:
- 目前的证据不足以支持或拒绝系统性抗生素用于VLU治疗.
- 局部 cadexomer显示承诺作为一个有效的治疗选项VLUs.
- 需要进一步进行高质量的研究,以澄清各种抗菌剂在VLU管理中的作用.
相关概念视频
Venous Thrombosis I: Introduction
478
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
478
Antimicrobial Effectiveness
1.0K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.0K
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.4K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.4K
Muscles that Move the Leg
5.4K
The movement of the legs is facilitated by numerous muscles located within the anterior, medial, and posterior compartments of the thigh.
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
5.4K
Venous Return
12.5K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.5K
Antimicrobial Proteins
14.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.5K


