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来自一个{CoNO}8复合体的NO−的质子诱导反应性

Melody A Rhine¹, Andria V Rodrigues, Ramona J Bieber Urbauer

¹Department of Chemistry and Center for Metalloenzyme Studies, The University of Georgia , Athens, Georgia 30602, United States.

Journal of the American Chemical Society

|July 30, 2014

概括

研究人员开发了一种-酸复合物,当被酸激活时,它充当酸 (HNO) 供体. 这一突破为潜在的治疗应用提供了HNO的新途径.

科学领域:

无机化学无机化学
药用化学医学化学
生物有机化学生物有机化学

背景情况:

氧化物 (NO) 的减少形式氧化物 (HNO) 的氧化物 (HNO) 显示出治疗潜力,但高度不稳定.
开发稳定的HNO供体分子对于其临床应用至关重要.
金属酸盐 (MNO) 复合物正在作为潜在的HNO输送系统进行研究.

研究的目的:

合成和表征一种具有潜在HNO捐赠能力的新型酸复合物.
为了研究合成的复合物与生物标的HNO释放特性.
为了探索酸复合物的反应性和稳定性.

主要方法:

合成和{CoNO}(8) 复合物的光谱/结构特征,在一个醇/胺基联体框架内.
测试复合物的HNO捐赠活性,并确定HNO目标,如铁 (III) 环和三 (Ph3P).
在各种条件下研究反应产物,包括存在酸,没有目标和与氧反应.

主要成果:

{CoNO}(8) 复合物[Co(LN4(PhCl))(NO) ] (1) 并没有与Fe(III) 半端或Ph3P直接发生反应.
综合体1证明了HNO捐赠者的行为,在史泰基测量H+的存在.
该复合物成功地将HNO转移到[Fe(TPP) Cl]和Ph3P,分别形成{FeNO}(7) 氨酸和Ph3PO/Ph3PNH.
由于没有目标,形成了dinitrosyl复合物 (3). 与O2的反应产生了一种酸盐模拟物 (2).

结论:

这项研究报告了第一个{CoNO}(8) 复合物作为HNO捐赠体的功能,特别是在质子化时针对生物点,如Fe(III) - 氨酸.
这些发现为设计用于治疗策略的基于金属的HNO捐赠剂开辟了新的途径.
反应性概况突出了反应条件在控制金属酸复合物的HNO释放方面的重要性.

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