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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

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Characteristics and Nomenclature of Homopolymers01:00

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Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
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Phosphodiester Linkages01:01

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Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
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聚烯核酸 (Poly) 是一种聚烯核酸.

Carrie R James1, Anthony M Rush, Thomas Insley

  • 1Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093, United States.

Journal of the American Chemical Society
|August 1, 2014
PubMed
概括
此摘要是机器生成的。

研究人员使用移植聚合制造创造了新的核酸聚合物. 这些多核酸 (PNA) 材料可以形成纳米粒子,并与DNA混合,促进生物材料的发展.

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科学领域:

  • 聚合物化学 聚合物化学
  • 生物材料科学 生物材料科学
  • 核酸化学的核酸化学

背景情况:

  • 基于核酸的聚合物为先进的应用提供了独特的特性.
  • 开发核酸单体的高效聚合方法至关重要.
  • 核酸 (PNA) 是具有诊断和治疗潜力的DNA模仿物.

研究的目的:

  • 为了合成聚 (?? 寡核酸) 刷聚合物和两性刷共聚合物.
  • 为了探索聚-PNA纳米颗粒的形成.
  • 为了研究这些PNA纳米结构与DNA的杂交能力.

主要方法:

  • 通过核酸单体的移植聚合.
  • 使用基于的启动器,对PNA-norbornyl单体进行环开转化聚合 (ROMP).
  • 两类块共聚物的自我组装成纳米粒子.
  • 用单链DNA (ssDNA) 进行杂交分析.

主要成果:

  • 成功制备了多聚 (?? 寡核酸) 刷聚合物和两性刷共聚合物.
  • 通过ROMP合成聚-PNA.
  • 聚-PNA纳米颗粒的形成来自两类块共聚合物.
  • 证明了聚-PNA纳米颗粒与互补的ssDNA的杂交.

结论:

  • 可高效合成多分子和共聚物质的多分子 (?? 基核酸) 刷.
  • 基于PNA的纳米粒子可以形成并表现出特定的DNA结合.
  • 这项工作为分子识别和诊断中的基于PNA的纳米结构提供了基础.