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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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在癌症中,RNA G-四重复体会导致eIF4A依赖的癌基因翻译

Andrew L Wolfe1, Kamini Singh2, Yi Zhong3

  • 11] Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA [3].

Nature
|August 1, 2014
PubMed
概括

细胞启动因子4A (eIF4A) RNA螺旋酶驱动癌症中的基因表达. 抗癌化合物Silvestrol针对这种机制,为白血病和其他癌症提供治疗潜力.

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