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抗真菌药物耐药性通过依赖RNAi的表皮突变引起

Silvia Calo1, Cecelia Shertz-Wall1, Soo Chan Lee1

  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nature
|August 1, 2014
PubMed
概括

甲状腺真菌 (Mucor circinelloides) 通过稳定的孟德尔基因突变或不稳定的表观遗传RNA干扰 (RNAi) 介导的fkbA基因沉默而发展出抗真菌药物耐药性.

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