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由C9orf72重复编码的多 dipeptides 结合核细胞,阻碍RNA生物发生,并杀死细胞

Ilmin Kwon1, Siheng Xiang1, Masato Kato1

  • 1Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA.

Science (New York, N.Y.)
|August 2, 2014
PubMed
概括

具有氨酸:氨酸 (SR) 域的RNA结合蛋白与hnRNPA2水凝结合. 通过CLK1/2的酸化逆转结合,而C9orf72疾病因破坏RNA生物发生而导致细胞死亡.

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