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模拟数字. 数字模型. 数字图案由Bmp-Sox9-Wnt图灵网络控制,该网络由形态变异梯度调节

J Raspopovic¹, L Marcon¹, L Russo¹

¹Systems Biology Program, Centre for Genomic Regulation (CRG), and Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.

Science (New York, N.Y.)

|August 2, 2014

概括

研究人员确定了关键的分子参与者,骨形态遗传蛋白 (Bmp),Sox9和Wnt信号传导,通过自我组织的图灵机制驱动四肢发育期间的数字形成.

科学领域:

发育生物学是发展生物学.
系统生物学系统生物学
计算建模计算建模

背景情况:

肢体的发育涉及从介质细胞组织中形成的数字.
提出了一个自我组织的图灵机制来控制数字模式.
这个机制的特定分子组成部分仍然未被确定.

研究的目的:

在肢体发育过程中识别分子网络驱动数字规范.
研究骨形态遗传蛋白 (Bmp),Sox9和Wnt信号在这个过程中的作用.
用计算模拟来建模和验证拟议的图灵机制.

主要方法:

实验研究与现实的二维计算建模相结合.
模拟数字图案的开发,包括形态变异梯度.
在野生类型和乱条件下分析基因表达模式.

主要成果:

有证据表明,一个涉及Bmp,Sox9和Wnt的图灵网络驱动数字规范.
计算模型成功地重复了Sox9的表达模式.
该模型准确地预测了野生类型和扰动实验中的模式.

结论:

一个基于Bmp,Sox9和Wnt的图灵网络,由形态梯度调节,是数字模式的基础.
这种系统生物学方法通过增长,梯度和自我组织证明了强大的模式形成.
这项研究阐明了脊椎动物四肢发育中的关键分子机制.

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