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Updated: Apr 26, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Published on: January 16, 2019

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与类素相关的严重皮肤不良反应相关的遗传变异

Wen-Hung Chung1, Wan-Chun Chang2, Yun-Shien Lee3

  • 1Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan2Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan3College of Medicine, Chang Gung University, Taoyuan, Taiwa.

JAMA
|August 7, 2014
PubMed
概括

遗传因素,特别是像CYP2C9*3这样的CYP2C变体,与因因而引起的严重皮肤不良反应有关. 这些变异降低了药物清除,增加了这些危险反应的风险.

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