尿白细胞化酶查试验用于男性无症状的克拉米迪亚和球菌感染
M A Shafer1, J Schachter, A B Moscicki
1Department of Pediatrics, University of California, San Francisco 94143.
JAMA
|November 10, 1989
概括
尿白细胞化酶测试有效地选了无症状的青少年男性的克拉米迪性和淋巴球菌性尿路炎. 这种非侵入性方法可以识别其他情况下无法检测到的感染,这对于公共卫生来说是具有成本效益的.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 青少年健康 青少年健康
背景情况:
- 引起的尿路炎 克拉米迪亚甲状腺菌和尼塞利亚淋病 在性活跃的青少年中很常见.
- 无症状感染由于潜在的并发症和进一步传播而构成重大公共卫生挑战.
- 有效的查方法对于早期发现和管理这一群体至关重要.
研究的目的:
- 评估尿白细胞化酶 (ULE) 试验的诊断准确性.
- 为了确定ULE测试能够预测培养验证的甲状腺炎和淋巴球菌尿路炎的能力.
- 评估ULE测试作为无症状青少年男性的查工具.
主要方法:
- 一组948名性活跃的青少年男性为ULE查提供了首次采集的尿样.
- 一组435名参与者接受了尿道培养,以检测克拉米迪亚甲状腺炎和尼塞里亚淋病.
- 计算了ULE测试的灵敏度,特异性和预测值.
主要成果:
- 在所有参与者的8%和接受培养的15%中,ULE测试呈阳性.
- 通过培养验证的感染包括9%的甲状腺炎和3%的尼塞利亚淋病.
- 试验结果显示,ULE测试的灵敏度为72%,特异性为93%,正预测值为58%,负预测值为96%.
结论:
- 尿白细胞化酶测试是一种有价值的,非侵入性查工具,用于无症状青少年男性的尿路炎.
- 这种具有成本效益的方法可以识别大量经过培养验证的克拉米迪亚菌和淋巴球菌感染.
- 实施ULE测试可以提高早期检测率,减少青少年性传播感染的负担.
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