Leu-8/TQ1是Mel-14淋巴结归向受体的人类对应物
D Camerini1, S P James, I Stamenkovic
1Department of Molecular Biology, Massachusetts General Hospital, Boston.
Nature
|November 2, 1989
概括
人类Leu-8抗原是Mel-14指向受体,对淋巴细胞粘附于淋巴结至关重要. 这一发现将淋巴细胞功能与组织分布和回归潜力联系起来.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 人类泛白细胞抗原Leu-8区分CD4+T淋巴细胞子集.
- -8在T细胞子集识别中的作用引起了人们的极大兴趣.
研究的目的:
- 为了识别小鼠Mel-14指向受体的人类同类.
- 调查Leu-8的功能和结构特征.
主要方法:
- 免疫学测定以鉴定Leu-8.的特征.
- 分子生物学技术用于识别同质.
- 分析Leu-8的细胞定位和定.
主要成果:
- 鉴定出Leu-8是小鼠Mel-14指向受体的人类同类.
- -8调解了淋巴细胞与外围淋巴结内皮的初始粘附.
- -8存在于常规形式和脂固形式.
结论:
- 鉴定Leu-8为Mel-14提供了对淋巴细胞指导机制的见解.
- 两种形式的Leu-8可能与抗原分泌和淋巴细胞激活有关.
- 淋巴细胞的功能类别可能与组织分布和本地化潜力有关.
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