减少Nm23/Awd蛋白在瘤转移和异常Drosophila发育中的发生
A M Rosengard1, H C Krutzsch, A Shearn
1Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.
Nature
|November 9, 1989
概括
降低nm23基因和蛋白质水平与瘤转移的增加相关. 这表明,对于发育至关重要的nm23/awd基因在丢失时可能会抑制癌症的进展.
科学领域:
- 在瘤学瘤学.
- 发育生物学 发展生物学
- 分子遗传学 分子遗传学
背景情况:
- 瘤转移是癌症相关死亡的主要原因.
- nm23基因的RNA水平与瘤转移潜力相反相关.
研究的目的:
- 为了识别和表征Nm23蛋白与瘤转移有关.
- 为了研究人类Nm23和Drosophila异常翼盘 (awd) 基因之间的同质性.
主要方法:
- 在转移性与非转移性瘤细胞中对nm23RNA和蛋白质的差异表达分析.
- 在人类Nm23和Drosophila awd.之间进行序列同质分析.
主要成果:
- Nm23蛋白质存在于细胞质和核两部分.
- 在高度转移的瘤细胞中,Nm23蛋白的表达显着较低.
- 人类Nm23与Drosophila awd具有广泛的序列同源性,Drosophila awd是一种参与发育的基因.
结论:
- nm23/awd基因家族在调节正常发育方面发挥作用.
- 失去nm23/awd基因功能可能导致癌症转移性表型.
- Nm23蛋白水平作为瘤转移潜力的潜在生物标志物.
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