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灵活的西格莫镜查对结直肠癌发病率和死亡率的影响:一项随机临床试验

Øyvind Holme¹, Magnus Løberg², Mette Kalager³

¹Department of Medicine, Sorlandet Hospital Kristiansand, Kristiansand, Norway2Institute of Health and Society, University of Oslo, Oslo, Norway3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts4Department of Biostatistics Harvard School of Public Health, Boston, Massachusetts.

|August 14, 2014

概括

在挪威的一项基于人口的试验中,灵活的西格莫多斯科比查显著降低了结直肠癌发病率和死亡率. 这种查方法在年轻人和老年人群中都被证明是有效的,为癌症预防提供了至关重要的工具.

科学领域:

在瘤学瘤学.
预防医学预防医学
公共卫生公共卫生

背景情况:

结肠直肠癌 (CRC) 是一个重大的全球健康挑战.
定期查是许多国家推的关键策略,以减轻CRC负担.

研究的目的:

评估灵活的西格莫显微镜查在减少CRC发病率和死亡率方面的有效性.
在以人口为基础的试验中,评估不同年龄人口群体的查有效性.

主要方法:

挪威的一项随机临床试验,涉及100,210名年龄在50-64岁的参与者.
参与者被随机分配到单独的灵活体镜或灵活体镜和便隐性血液检测 (FOBT) 的组合,与没有干预的对照组相比.
随访数据收集到2011年12月31日,随访时间中位数为10.9年.

主要成果:

与没有查相比,灵活的西格米多斯科普查减少了20%的CRC发病率 (HR,0.80) 和27%的死亡率 (HR,0.73).
在50-54岁年龄组 (发病率HR,0.68) 和55-64岁年龄组 (发病率HR,0.83) 均观察到这些益处.
单独使用柔性半导体镜和与FOBT结合使用之间没有发现显著的结果差异.

结论:

有或没有FOBT,只进行一次灵活的半导体镜检查,可以有效降低CRC发病率和死亡率在人口层面.
查干预措施在年轻 (50-54岁) 和年长 (55-64岁) 成年人年龄组均显示出有效性.
灵活的半导体镜作为一个有价值的人口层面查工具,用于预防结直肠癌.

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