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在发育过程中不适当的p53激活会诱导CHARGE综合征的特征

Jeanine L Van Nostrand1, Colleen A Brady2, Heiyoun Jung1

  • 1Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|August 15, 2014
PubMed
概括

在发育过程中瘤抑制剂p53的不适当激活会导致CHARGE综合征表型. 这一发现揭示了p53在发育障碍中的关键作用,并为CHARGE综合征机制提供了新的见解.

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