慢性阻塞性肺病的风险因素和早期起源
Dirkje S Postma1, Andrew Bush2, Maarten van den Berge1
1Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Lancet (London, England)
|August 16, 2014
概括
早期的生活暴露,不仅仅是吸烟,显著影响慢性阻塞性肺病 (COPD) 的发展. 了解这些不同的风险因素对于管理这种异质性肺部疾病至关重要.
科学领域:
- 肺部医学 肺部医学
- 环境健康 环境健康
- 发育儿科 发育儿科
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题,主要与吸烟有关.
- 虽然在临床上在中年时明显,但COPD的起源可以追溯到生命早期的暴露.
- 目前的COPD诊断严重依赖于肺功能,忽视了疾病的异质性.
研究的目的:
- 审查有关COPD早期生命风险因素的证据.
- 探索不同生命阶段和COPD表型的风险因素.
- 为了突出COPD发展的异质性.
主要方法:
- 对COPD风险因素研究的文献综述.
- 从产前和幼儿时期的证据分析.
- 检查导致各种COPD表型的风险因素.
主要成果:
- 产前和幼儿时期的环境暴露是导致COPD的重要因素.
- 不同的风险因素影响着不同的COPD表型.
- 生命早期的因素启动了一种疾病过程,导致生命后期的临床表现.
结论:
- 慢性肺炎的发展是多因素的,具有重要的早期影响.
- 解决早期生命风险因素可能为COPD预防和管理提供新的途径.
- 承认COPD异质性对于有针对性的干预措施至关重要.
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