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循环omega-6多不和脂肪酸和总和因特定死亡率:心血管健康研究

Jason H Y Wu¹, Rozenn N Lemaitre², Irena B King²

¹From The George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.H.Y.W.); Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle (R.N.L., B.M.P.); the Department of Internal Medicine, University of New Mexico, Albuquerque (I.B.K.); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (X.S.); the Department of Epidemiology and Health Service, University of Washington, Seattle (B.M.P.); Group Health Research Institute, Group Health Cooperative, Seattle, WA (B.M.P.); New York Academy of Medicine, New York (D.S.S.); and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.). jwu1@georgeinstitute.org.au.

|August 16, 2014

概括

较高的林诺酸水平与老年人死亡率的降低有关,特别是由于心血管原因. 这表明这种omega-6多不和脂肪酸 (n-6PUFA) 具有保护作用.

科学领域:

心血管健康心血管健康
营养流行病学营养流行病学
欧米茄6脂肪酸欧米茄6脂肪酸

背景情况:

建议使用omega-6多不和脂肪酸 (n-6PUFA) 来降低冠状动脉心脏病 (CHD),但人们对潜在的促炎作用存在担忧.
心血管健康研究调查了美国社区基队列中循环n-6PUFA和死亡率之间的关联.

研究的目的:

检查特定的n-6PUFA,包括酸在内的循环水平与总和因特定死亡率之间的关系.
澄清n-6PUFA在心血管健康和整体生存期方面的潜在益处与危害.

主要方法:

在2792名参与者 (年龄≥65岁) 中测量了血脂n-6PUFA水平,在基线时没有心血管疾病.
所有原因和特定原因死亡率,发病性心血管疾病和中风都被评估并判定为10.7年的中位随访时间.
考克斯回归模型被用于评估PUFA与风险的关联,并对相关共变量进行调整.

主要成果:

较高的林诺酸水平与较低的总死亡率 (HR=0.87,P趋势=0.005) 和心血管疾病死亡率显著相关,特别是非失常性心血管疾病死亡率 (HR=0.51,P趋势=0.001).
其他测量的n-6PUFA,包括阿拉基酸,与总死亡率或因特定原因死亡率没有显著关联.
酸和死亡率之间的反向关联是分级的,并且在各个子组中一致,当n-6和n-3PUFA水平高时,观察到的风险最低.

结论:

在老年人中,循环中氨基酸的升高与总和冠心病死亡率相反相关.
这些发现表明,酸具有潜在的保护作用,挑战了对一般n-6PUFA危害的担忧.
进一步的研究可能会阐明林酸对心血管的益处背后的机制.

关键词:

心血管疾病心血管疾病流行病学流行病学脂肪酸,欧米茄-6 脂肪酸.死亡率死亡率

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