泰拉米网状子网络的国家依赖的架构
Michael M Halassa1, Zhe Chen2, Ralf D Wimmer1
1Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA; Department of Neuroscience & Physiology, New York University Langone Medical Center, New York, NY 10016, USA; Department of Psychiatry, New York University Langone Medical Center, New York, NY 10016, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|August 16, 2014
概括
胸膜网状核 (TRN) 包含不同的子网络,这些子网络根据行为状态差异性调节胸膜皮层相互作用,控制用于认知的感官和边缘处理.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 认知神经科学 认知神经科学
背景情况:
- 行为状态显著影响着对感觉,行动和认知至关重要的乳头皮层相互作用.
- 乳头网状核 (TRN) 是这些相互作用的关键调节者,但其功能架构和状态依赖调节仍然不清楚.
研究的目的:
- 阐明TRN的功能架构及其对thalamo-cortical电路的状态依赖调节.
- 研究不同TRN子网络如何调节不同行为状态的感官和边缘处理.
主要方法:
- 结合TRN组合录音,心理物理和基于连接的光遗传标记.
- 在不同的行为状态 (兴奋,睡眠,注意力) 中研究神经活动模式.
- 利用子网络特定的光遗传刺激来操纵注意力表现.
主要成果:
- 确定了具有差异投射目标 (边缘与感官) 的独特TRN子网络.
- 边缘投射TRN神经元与唤醒相关;感觉投射神经元在睡眠期间表现出状态依赖的活动 (螺旋,缓慢波),并在注意力期间被抑制.
- 通过传感投射TRN神经元证明了状皮层相互作用的状态匹配门.
- 通过特定子网络的光遗传刺激,显示了对注意力表现的双向操纵.
结论:
- 该TRN由功能上不同的子网络组成,这些子网络根据行为状态差异性抑制thalamic核.
- TRN单独控制外部感官和内部边缘处理,这对正常认知功能至关重要.
- 这些发现揭示了TRN对大脑功能的状态依赖调节的新机制.
相关概念视频
Functional Brain Systems: Reticular Formation
5.5K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.5K
Diencephalon: Thalamus and Information Relay
4.8K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
4.8K
Diencephalon: Anatomical Regions
5.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
5.9K
Diencephalon: Hypothalamus and Coordination
4.5K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
4.5K
Neural Circuits
3.0K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.0K
Brainstem
7.4K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
7.4K


