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三甘油和心血管疾病
Børge G Nordestgaard1, Anette Varbo1
1Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lancet (London, England)
|August 19, 2014
概括
升高的甘油三水平越来越被认为是心血管疾病和死亡的重要危险因素. 新的降甘油三类药物和正在进行的试验旨在证实它们对心血管的益处.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 药理学 药理学是指药理学的学科.
背景情况:
- 临床重点已经从LDL胆固醇和HDL胆固醇转移到甘油三.
- 遗传和流行病学证据突出显示,甘油三,残留胆固醇和富含甘油三脂蛋白是心血管疾病 (CVD) 的危险因素.
- 低HDL胆固醇可能不会像以前认为的那样引起心血管疾病.
研究的目的:
- 审查当前对甘油三在心血管疾病中的作用的理解.
- 讨论新证据和药物开发对三糖管理的影响.
主要方法:
- 对遗传研究和随机对照试验的审查.
- 对有关三甘水平和心血管风险的流行病学数据的分析.
- 讨论当前和新兴的降甘油三治疗方法.
主要成果:
- 在2-10mmol/L之间的甘油三度与心血管疾病风险增加有关.
- 高于10mmol/L的甘油三水平增加了急性胰腺炎和潜在的心血管疾病的风险.
- 在随机试验中,支持降低甘油三的心血管益处的证据有限,但正在出现.
结论:
- 人们重新对甘油三作为心血管疾病的关键因素产生兴趣.
- 新的降甘油三醇药物正在开发中,正在进行大规模试验.
- 目前正在进行的研究预计将从正在进行的研究中获得有关降低甘油三的心血管益处的确证据.
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