氧度对支气管炎住院治疗的影响:一项随机临床试验
Suzanne Schuh1, Stephen Freedman2, Allan Coates3
1Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada2Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
JAMA
|August 21, 2014
概括
在患有支气管炎的婴儿中人工提高脉冲氧计读数显著降低了住院率. 这项研究建议重新评估氧和度.
科学领域:
- 儿科急救医学 儿科急救医学
- 呼吸系统疾病 呼吸系统疾病
- 临床试验方法论 临床试验方法论
背景情况:
- 常规的脉冲氧计使用影响支气管炎的管理.
- 由于氧度测量,有可能降低住院门.
- 需要调查显示与真实氧和度的影响.
研究的目的:
- 为了确定人工升高的脉冲氧计读数 (3%以上) 是否会减少患有支气管炎的婴儿住院治疗.
- 为了比较接受真实与改变氧度测量的婴儿之间的住院率.
主要方法:
- 随机,双盲,并行组试验 (2008-2013) 在儿科急诊室.
- 213名婴儿 (4周至12个月) 患有轻度至中度支气管炎,真实和率≥88%.
- 干预:显示的氧度计读数的人工提高了3%与真实读数相比.
主要成果:
- 在72小时内住院治疗发生在25%的改变氧度组和41%的真氧度组 (16%的差异,P=.005).
- 在调整医生影响后,初级治疗效应仍然显著 (aOR,4.0;P=.009).
- 在二次结果中没有显著差异,包括额外的氧气使用或非计划的访问.
结论:
- 人工升高的脉冲氧计读数降低了支气管炎的婴儿住院率.
- 研究结果表明,仅仅氧和量不应决定入院决定.
- 重新评估脉冲氧计在支气管炎管理中的作用是有必要的.
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