通过两种APC/C化学抑制剂对线粒细胞退出的协同阻断

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Katharine L Sackton1, Nevena Dimova1, Xing Zeng1

  • 11] Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA [2].

Nature
|August 27, 2014
PubMed
概括

癌症治疗可以向促进酶复合体/循环体 (APC/C),这是一个调节细胞分裂的蛋白质机器. 一种新的抑制剂,apcin,通过破坏关键蛋白相互作用来阻断APC/C活性,提供了一个潜在的治疗策略.

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