节点信号确定了Hydra中的二射线不对称性
Hiroshi Watanabe1, Heiko A Schmidt2, Anne Kuhn1
1Department of Molecular Evolution and Genomics, Centre for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany.
Nature
|August 27, 2014
概括
在Hydra中,一个与节点相关的基因 (Ndr) 建立了轴性不对称性,影响了芽和身体轴形成. 这表明,一个保存的信号通路可以追溯到类动物和双边动物之间的分裂之前.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 双边人有三个身体轴 (前后,背内,左右) 受到特定信号因子的调节.
- 双胞胎的姐妹Cnidarians,在一个口腔-腹腔轴上表现出双胞胎性,具有未知的分子基础.
研究的目的:
- 为了研究在CnidarianHydra中轴不对称的分子基础.
- 探索身体轴图案路径的进化起源.
主要方法:
- 在Hydra magnipapillata.中识别和分析一个节点相关基因 (Ndr).
- 调查Ndr在轴不对称性和芽形成中的作用.
- 检查Ndr,Pitx和β-Catenin信号之间的关系.
主要成果:
- 在Hydra中确定了一种与节点相关的基因 (Ndr),并发现它对轴性不对称性至关重要.
- Ndr建立了一个侧向信号中心,在芽的息肉中诱导一个新的身体轴.
- Ndr 作用于 β-Catenin 信号的下游,并诱导转录因子 Pitx,反映脊椎动物节点功能.
结论:
- 一个核心信号录音带 (β-Catenin,Nodal,Pitx) 已存在于cnidarian-bilaterian分裂之前.
- 这张录音带很可能被选择用于各种各样的轴向图案角色,包括 cnidarians 的横向分支和 bilaterians 的左右图案.
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