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通过自由α-环球蛋白对HSP70的绑定促进了β-thalassaemia中无效的 erythropoiesis

Jean-Benoît Arlet1, Jean-Antoine Ribeil2, Flavia Guillem3

  • 11] Laboratoire INSERM, unité mixte de recherche 1163, centre national de la recherche scientifique (CNRS) équipe de recherche labellisée 8254, 24 Boulevard de Montparnasse, 75015 Paris, France [2] Service de Médecine Interne, Faculté de médecine Paris Descartes, Sorbonne Paris-Cité et Assistance publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 15 rue Leblanc 75908 Paris, France [3] Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, Assistance publique - Hôpitaux de Paris, Hôpital Necker, 24 Boulevard de Montparnasse, 75015 Paris, France [4] Laboratory of Excellence GR-Ex, 75015 Paris, France [5].

Nature
|August 27, 2014
PubMed
概括

在β-thalassaemia重大中,热冲击蛋白70 (HSP70) 通常保护GATA-1,但被过量的α-globin所困住. 这导致红细胞亡,这表明HSP70或GATA-1突变作为治疗方法.

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