价值的双向切换与海马上下文记忆电图相关
Roger L Redondo1, Joshua Kim2, Autumn L Arons3
11] RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [3].
Nature
|August 28, 2014
概括
这项研究发现,背部牙状回形 (DG) 通过与相反的刺激重新激活其内图,可以逆转记忆价值. 这与桃体 (BLA) 的基侧综合体形成鲜明对比,显示DGD.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 行为心理学 行为心理学
背景情况:
- 由于其重建性质,记忆价值是可塑的,对不适应行为有临床应用.
- 基础上的神经元机制和大脑电路记忆价值切换仍然在很大程度上未被探索.
研究的目的:
- 调查神经机制和大脑电路参与切换记忆的价值.
- 探索记忆录的可塑性,以扭转情感关联.
主要方法:
- 利用光遗传技术标记和操纵桃体的背部牙状回环 (DG) 和底侧综合体 (BLA) 中的记忆引进细胞.
- 应用通道罗多普辛-2 (ChR2) 在恐惧和奖励条件化范式期间用于细胞操纵.
- 通过在原始engram重新激活过程中用相反价值的刺激重新调节受试者来评估记忆价值逆转.
主要成果:
- 无论是DG和BLA发酵细胞,当被重新激活时,都会引起与最初的恐惧或奖励条件一致的有条件反应.
- 用相反的价值刺激进行重新调节,在DG-engram组中成功逆转了记忆价值,但在BLA-engram组中没有.
- 细胞层面的分析显示,在价值逆转后,DG engram细胞之间的功能连接发生了变化.
结论:
- 背部牙状回形 (DG) 在它的记忆引擎中表现出可塑性,允许扭转受条件的情感价值.
- 再激活DG电图与新的,相反的无条件刺激相结合,可以逆转受条件反应的价值.
- 这些发现为控制情绪记忆可塑性的神经回路提供了新的见解,突出了DG和BLA的不同角色.
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