对远处物种的监管信息和电路进行比较分析
Alan P Boyle1, Carlos L Araya1, Cathleen Brdlik2
11] Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA [2].
Nature
|August 29, 2014
概括
基因调节网络在人类,和虫等物种中表现出保存的特性,揭示了元动物调节的基本原则. 这种比较分析加深了我们对生物学和疾病的理解.
科学领域:
- 进行比较的基因组学.
- 分子生物学分子生物学
- 进化生物学是进化的生物学.
背景情况:
- 甲动物物种表现出生物学上的共同点,尽管进化距离很远,为人类生物学研究建立了像和虫这样的模型生物.
- 之前的研究探讨了基因调节的相似性,但缺乏对转录调节特征的大规模比较分析.
研究的目的:
- 对人类,和虫中转录调节因子的全基因组结合位置进行大规模比较分析.
- 在转录性调节特征和基因调节网络中确定保存原则.
主要方法:
- 对165个人类,93个虫和52个菌因子的转录调节因子结合部位的全基因组映射.
- 来自不同细胞类型,发育阶段和条件的1019个数据集的生成.
- 对正统的调节因子家族的结合动机和共同关联的分析.
主要成果:
- 调节网络的结构性质在研究的物种中得到了显著的保护.
- 正义调节因子家族在体内识别出类似的结合动机.
- 观察到有证据表明,监管因素之间的共同关联得到保护.
结论:
- 基因调节性质是元动物调节的一般原则,尽管有功能差异,但保存得很好.
- 监管电路的比较地图增强对模型生物体生物学及其与人类生物学,发育和疾病的关系的理解.
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