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发现和描述一种与二硫化物锁定的C(2) - 对称的防御蛋白

Andrew J Wommack1, Joshua J Ziarek, Jill Tomaras

  • 1Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

Journal of the American Chemical Society
|September 3, 2014
PubMed
概括

研究人员发现了HD5-CD,这是一种人类防御素5 (HD5) 的新型共价二元体. 这种独特的结构增强了抗微生物活性和蛋白酶耐药性,为抗Acinetobacter baumannii等病原体提供了新的治疗潜力.

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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