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Updated: Apr 24, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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重编程纤维细胞到内皮细胞:转化或重生?

Lianghui Zhang¹, Asrar B Malik¹, Jalees Rehman²

¹From the Section of Cardiology, Department of Medicine ( L.Z., J.R.), and Department of Pharmacology (L.Z., A.B.M., J.R.), University of Illinois at Chicago, College of Medicine, Chicago.

|September 5, 2014

概括

No abstract available in PubMed .

关键词:

社论社论社论社论细胞分化的细胞分化.它们是内皮细胞的内皮细胞.复兴再生是一种再生方式.干细胞是干细胞的组成部分.

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Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...