SPEECHLESS在口腔自我更新细胞的规范中的直接作用
On Sun Lau1, Kelli A Davies1, Jessica Chang1
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|September 6, 2014
概括
无声 (SPCH) 控制植物干细胞的分裂和细胞命运. 这项研究揭示了SPCH.
科学领域:
- 植物生物学 植物生物学
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
背景情况:
- 血统特异性干细胞对于多细胞生物的组织发育和维护至关重要.
- 在Arabidopsis中,转录因子SPEECHLESS (SPCH) 调节了口腔系细胞的启动和增殖.
- 通过SPCH控制口腔血统细胞行为的精确机制在很大程度上是未知的.
研究的目的:
- 在体内调查Arabidopsis SPCH转录因子的全基因组标.
- 阐明SPCH控制的调节口腔发育的分子通路.
- 了解SPCH如何影响植物干细胞系的细胞命运决策和细胞间通信.
主要方法:
- 改进的染色体免疫沉 (ChIP) 测定技术.
- 在Arabidopsis中SPCHDNA结合点的全基因组概况.
- 对参与细胞命运调节和细胞间信号传递的SPCH目标基因的分析.
主要成果:
- 在口腔系内,SPCH直接调节参与细胞命运决定的关键基因.
- 在SPCH控制基因,这些基因对于执行不对称的细胞分裂在发育的口腔中至关重要.
- SPCH调节植物对和植物激素信号的反应,影响细胞通信.
- 识别SPCH结合的基因组区域提供了其监管网络的全面地图.
结论:
- SPCH 是一个中心调节器的口腔血统干细胞行为在Arabidopsis.
- 该研究描述了SPCH整合细胞命运,分裂和细胞间通信的分子通路.
- 研究结果提供了关于植物中必不可少的成年干细胞系的调节的见解.
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