临床概况和对急性心膜炎住院患者的临床结果的影响
Ville Kytö1, Jussi Sipilä2, Päivi Rautava2
1From the Heart Center, (V.K.), Clinical Neurosciences, Neurology (J.S.), and Clinical Research Center (P.R.), Turku University Hospital, and PET Center (V.K.), Neurology (J.S.), and Public Health (P.R.), University of Turku, Turku, Finland. ville.kyto@utu.fi.
Circulation
|September 11, 2014
概括
急性心膜炎在男性中更为常见. 由于急性心膜炎的住院死亡率随着年龄和严重的同时感染而增加,但不是性别.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 急性心膜炎的临床特征,特别是关于性别差异和结果预测因素,尚不清楚.
- 现有研究尚未完全阐明急性心膜炎住院患者的人口和临床特征.
研究的目的:
- 调查临床特征,重点关注基于性别的差异,并确定影响急性心膜炎住院患者结果的因素.
- 确定急性心膜炎住院病例的发病率和人口分布.
主要方法:
- 一项全国性的回顾性研究,利用芬兰国家心血管病入院登记册超过9.5年的时间.
- 分析包括16岁及以上患者中1361例急性心膜炎入院病例,但不包括特殊类型的心膜炎,如心膜炎术后和心肌梗塞相关心膜炎.
- 统计方法包括年龄调整的概率比率,相对风险计算和多变量分析来评估死亡率预测因素.
主要成果:
- 急性心膜炎在男性 (64.9%) 比女性 (35.1%) 更为普遍,在16-65岁的男性中观察到更高的风险.
- 急性心膜炎住院的标准化发病率为每10万人/年3.32,发病率随着年龄的增长而下降.
- 住院死亡率为1.1%,随着年龄和严重共感染 (肺炎或败血症) 的存在显著增加,但与性别无关.
结论:
- 男性性别是急性心膜炎住院的重要人口因素.
- 高龄和严重的共感染是急性心膜炎患者医院死亡率增加的关键预测因素.
- 性别似乎不是急性心膜炎的住院死亡率的独立预测因素.
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