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在CTLA4中具有异合体生殖系突变的人体免疫调节失调

Hye Sun Kuehn1, Weiming Ouyang2, Bernice Lo3,4

  • 1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|September 13, 2014
PubMed
概括

细胞毒性T淋巴细胞抗原-4 (CTLA-4) 的突变会导致人类严重的免疫失调,影响T和B细胞平衡. 这突出了CTLA-4的亮点.

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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