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Updated: Apr 24, 2026

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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在ERAD中的关键步骤是用净化组件复制的光ER蛋白质

Alexander Stein1, Annamaria Ruggiano2, Pedro Carvalho2

  • 1Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Cell
|September 13, 2014
PubMed
概括

这项研究揭示了错误折叠的ER蛋白如何被输送到细胞质中进行降解. Hrd1p结合酶形成了一个导体,Cdc48p提取无处不在的蛋白质用于蛋白质体处理.

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