治疗性蛋白质聚合物合物:超越PEGylation的发展
Emma M Pelegri-O'Day1, En-Wei Lin, Heather D Maynard
1Department of Chemistry and Biochemistry and California Nanosystems Institute, University of California, Los Angeles , 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.
Journal of the American Chemical Society
|September 13, 2014
概括
蛋白质聚合物结合物,就像PEGylated药物一样,提供治疗效益. 研究正在探索替代聚合物,以克服PEG的局限性,并增强具有更好的特性的蛋白质疗法.
科学领域:
- 生物结合化学的化学
- 制药科学 制药科学
- 药物输送系统是药物输送系统.
背景情况:
- 蛋白质聚合物合物,特别是聚乙烯糖醇 (PEG) 合物,是FDA批准的重要治疗药物.
- 基化增长了药物的半衰期,减少了剂量频率,并改善了患者的服药性.
- 由于PEG的局限性,需要开发替代的聚合物技术.
研究的目的:
- 审查当前治疗用途中的蛋白质-PEG合物.
- 总结用于蛋白质治疗的替代聚合物技术.
- 建议未来的蛋白质结合研究方向.
主要方法:
- 对蛋白质-PEG结合物生产的既定方法的审查.
- 探索使用可控基聚合物用于替代合物的新方法.
- 分析蛋白质聚合物系统的药理动力学特性和稳定性.
主要成果:
- 蛋白质-PEG结合物是现代疗法的基石,因为它们的循环时间延长了.
- 替代性聚合物正在出现,它们有可能提高稳定性和生物降解性.
- 控制的激素聚合,为聚合提供了对聚合物结构的精确控制.
结论:
- 聚合物科学的进步对于开发下一代蛋白质疗法至关重要.
- 对PEG的替代聚合物有望克服当前的局限性并扩大治疗应用.
- 未来的研究应该专注于新的结合策略和材料,以改善蛋白质药物输送.
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