血细胞 dendritic 细胞的 MHC II 类受限抗原呈现驱动 proatherogenic T 细胞免疫力
Andrew P Sage1, Deirdre Murphy1, Pasquale Maffia1
1From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (A.P.S., D.M., L.M.M., L.L.B., A.J.F., J.E.H., Z.M.); Centre for Immunobiology, Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom (P.M., S.R.S., H.C., G.G.); Institut National de la Santé et de la Recherche Médicale, Unit 970, Paris Cardiovascular Research Center, Paris, France (H.A., Z.M.); the Department of Pharmacy, University of Naples Federico II, Naples, Italy (P.M., G.G.); Institute of Immunobiology, Kantonal Hospital St. Gallen, CH-9007 St. Gallen, Switzerland (B.L.); the Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland (W.R.); Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden (G.K.H.); the Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY (B.R.); and the Department of Pathology, University of Geneva Medical School, CH-1211 Geneva, Switzerland (S.H.).
血类树突细胞 (pDCs) 通过向T细胞呈现抗原来促进动脉样硬化. 阻止这种功能可以减少动脉样硬化,突出显示pDCs是心血管疾病的治疗目标.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管研究研究心血管研究
- 动脉样硬化是一种动脉样硬化.
背景情况:
- 等离子体树突细胞 (pDCs) 是免疫反应的关键调节者.
- 对于pDCs在动脉样硬化 - - 一种主要的免疫-炎症性疾病中的作用 - - 尚不清楚.
研究的目的:
- 研究pDCs在动脉样硬化发展中的作用.
- 阐明pDCs影响动脉样硬化的机制.
主要方法:
- 在Ldlr-/-) 小鼠中使用遗传方法,在pDCs上产生选择性的pDC缺乏和MHCII缺乏.
- 分析了动脉样硬化水平,T细胞反应和免疫细胞透.
主要成果:
- 选择性pDC缺陷降低了小鼠的动脉样硬化水平.
- 缺乏MHCII的pDCs显示CD4 ((+) T细胞的刺激受损,并减少了T细胞的益风性反应.
- 在患有MHCII缺乏pDCs的小鼠中观察到T细胞透和干扰素-γ生产的减少.
结论:
- pDCs在小鼠动脉样硬化中起着益风性作用.
- 通过pDCs进行的MHCII受限抗原呈现对于驱动益风性T细胞免疫力至关重要.
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