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Updated: Apr 23, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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对Gleevec和G6G的计算研究揭示了激酶抑制剂选择性的分子决定因素

Yen-Lin Lin1, Yilin Meng, Lei Huang

  • 1Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, The University of Chicago , 929 57th Street, Chicago, Illinois 60637, United States.

Journal of the American Chemical Society
|September 23, 2014
PubMed
概括

激酶抑制剂G6G,与Gleevec不同,有效地准了Abl和c-Src激酶. 分子动力学模拟显示了G6G.

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