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行为变化通过随机选择和它的门由前带皮层前带皮层
Dougal G R Tervo1, Mikhail Proskurin1, Maxim Manakov1
1Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Cell
|September 27, 2014
概括
当面对无敌的竞争对手时,老鼠从战略决策转换为随机模式. 这种行为转变,由前带皮层 (ACC) 输入的coeruleus位置控制,允许在不确定性下进行探索.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 计算神经科学是一种神经科学.
背景情况:
- 动物通常使用过去的经验来优化决策.
- 然而,探索和不可预测性也对生存至关重要.
- 在这些行为策略之间切换的基础的神经机制尚未完全理解.
研究的目的:
- 研究老鼠如何在战略和随机行为模式之间切换.
- 为了确定控制这种行为灵活性的神经回路.
- 了解前带状皮质 (ACC) 和状部 (LC) 在不确定性下决策中的作用.
主要方法:
- 与面对虚拟竞争对手的老鼠进行行为实验.
- 转基因大鼠中的电路干扰.
- 电生理学记录和光遗传学操纵.
- 在ACC和LC中分析行为策略和神经活动.
主要成果:
- 老鼠使用历史和基于模型的策略来对抗可预测的竞争对手.
- 当面对不可预测的竞争对手时,老鼠会切换到随机模式,无视结果.
- 这种开关是通过向前带带皮层 (ACC) 输入的coeruleus位介导的.
- 在随机行为期间观察到ACC参与的抑制.
结论:
- 大脑可以在根据经验优化行为和采用不可预测的策略之间切换.
- 在前环皮质 (ACC) 输入的Locus coeruleus (LC) 控制了这种行为灵活性.
- 在环境不确定性下,ACC输出的诺亚氨基调制使得适应性决策成为可能.
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