在先天性长QT综合征中的电生理基质:用心电成像 (ECGI) 进行非侵入性映射
Ramya Vijayakumar1,2, Jennifer N A Silva1,3, Kavit A Desouza4
1Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, Saint Louis, MO.
Circulation
|October 9, 2014
概括
生产性长QT综合征 (LQTS) 患者表现出区域复极异常,在标准心电图上看不到. 这些发现表明,心电图像可能有助于对LQTS患者风险进行分层.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医疗成像医学成像
背景情况:
- 先天性长QT综合征 (LQTS) 是一种遗传性疾病,会导致昏和突然死亡.
- 将LQTS突变与人类心律失常易感性联系在一起的确切机制尚不清楚.
- 使用非侵入式心电图成像来研究LQTS中的心脏电生理学基质.
研究的目的:
- 使用心电图像绘制LQTS患者的心脏电生理基质的映射.
- 为了确定LQTS患者是否表现出区域再极化异质性.
- 评估复极异常与临床症状之间的关系.
主要方法:
- 对25名LQTS患者 (LQT1,LQT2,LQT3,LQT5) 和7名对照进行了心电图像.
- 创建了激活,恢复时间,激活-恢复间隔和再极化分散的心图.
- 分析的重点是比较LQTS患者和对照组之间的复极化参数.
主要成果:
- 与对照组相比,LQTS患者的恢复时间和激活-恢复间隔延长.
- 激活-恢复间隔的延长在空间上是异质的,反极化梯度明显更.
- 再极化梯度在有症状的LQTS患者中比无症状患者更.
结论:
- 患有LQTS的患者具有局部区域的延长作用潜力的持续时间,导致急剧的再极化分散.
- 这种分散形成了回入性心律失常的基质,表面心电图无法检测到.
- 电脑心电图像可能对LQTS中的风险分层有价值,特别是在有症状的个体.
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