来自藻类和细菌前体分子的杀菌剂的混合生物合成
Mohammad R Seyedsayamdost1, Rurun Wang, Roberto Kolter
1Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States.
Journal of the American Chemical Society
|October 9, 2014
概括
海洋细菌和藻类有一个共生关系,可以变成寄生虫. 细菌转移有益的分子产生毒素,调节这个开关.
科学领域:
- 海洋微生物学 海洋微生物学
- 共生相互作用的共生相互作用.
- 生物化学 生物化学
背景情况:
- 菌和Emiliania huxleyi形成了一个共生.
- 这种关系可以是相互的或寄生性的.
- 寄生病是由藻类衰老和p-酸释放引发的.
研究的目的:
- 为了研究杀菌剂的生物合成.
- 了解杀菌剂前体在共生中的作用.
- 阐明从互惠主义转向寄生主义的转变.
主要方法:
- 对杀菌剂生物合成途径的分析.
- 在共生过程中检查前体分子功能.
- 杀菌剂组装的拟议机制.
主要成果:
- 在互惠阶段,杀药前体是必不可少的.
- 在寄生虫的过程中,有益的分子被重新用于毒素合成.
- P-酸触发了开关和杀菌剂的生产.
结论:
- 杀菌剂调节了海洋细菌-藻类共生.
- 这项研究揭示了共生开关的分子机制.
- 有益的化合物被转移到产生藻类毒素.
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