催产素通过一类特定的前额叶皮层内部神经元调节女性的社会性行为
Miho Nakajima1, Andreas Görlich1, Nathaniel Heintz1
1Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Cell
|October 11, 2014
概括
在中部前额皮质 (mPFC) 中的催产素 (OT) 信号影响社会行为. 表达催产素受体 (OxtrINs) 的特定内部神经元对于雌性小鼠的社会兴趣至关重要.
科学领域:
- 神经科学是一个神经科学.
- 社会行为 社交行为
- 激素信号传递 激素信号传递
背景情况:
- 鼻内催产素 (OT) 激活了人类的前额叶皮质,与自闭症患者改善的大脑功能相关.
- 精确的神经回路中介OT对社会行为的影响尚未完全理解.
研究的目的:
- 为了确定特定的神经元群体参与中介前额叶皮层 (mPFC) 中的催产素信号传递.
- 研究这些神经元在调节雌性小鼠社会行为的作用.
主要方法:
- 发现和表征表达催产素受体 (OxtrINs) 的体静止素阳性内部神经元.
- 在雌性小鼠的mPFC中对OxtrINs进行光遗传沉默.
- 在mPFC中条件删除催产素受体 (Oxtr) 基因.
- 使用一个Oxtr对抗剂.
主要成果:
- 在雌性小鼠的mPFC中抑制oxtrINs,特别减少了在雌性周期的受体阶段对雄性小鼠的社会兴趣.
- 这种社会性缺陷在mPFC中的条件Oxtr删除和Oxtr对抗剂输液的小鼠中复制.
- 这些发现突出了OT/Oxtr信号传递的性别,细胞类型和特定状态的作用.
结论:
- 通过OxtrINs介导的mPFC中的催产素/催产素受体 (OT/Oxtr) 信号传递,在调节雌性小鼠的社会性行为方面发挥着关键作用.
- 这项研究发现了一种新的皮质电路元件,它参与调节复杂的社会行为.
- 这些发现表明,社会功能障碍的潜在治疗点.
相关概念视频
Neurotransmitters
3.7K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
3.7K
Hormonal Control of the Ovarian Cycle
5.0K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
5.0K
Socioemotional Experience and Gender Development
419
Social-emotional experiences and cultural influences play significant roles in shaping gender development. During middle childhood, from ages 6 to 11, peer groups become dominant in reinforcing gender norms. Children in this age group often align with same-gender peer groups, which actively encourage behaviors that conform to traditional gender roles. For instance, boys may be discouraged from engaging in activities perceived as feminine, reinforcing culturally dictated norms about masculinity...
419
Feedback Regulation of Calcium Concentration
2.9K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
2.9K
Causes of Social Behavior II: Cognitive Processes
295
Cognitive processes affect social behavior by guiding how individuals perceive, interpret, and respond to social stimuli. These mental processes enable individuals to assess others' behaviors, attribute causes to their actions, and form expectations based on past experiences.Causes of Behavior and Social JudgmentsIndividuals determine the causes of others' behaviors by distinguishing between personal traits and external circumstances. For example, if a friend frequently arrives late, an...
295
Facial Feedback Hypothesis
935
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
935


