在生物功能组件中,pH值和两性结构直接影响了超分子行为
Tyson J Moyer1, Joel A Finbloom, Feng Chen
1Institute for BioNanotechnology in Medicine and ∥Department of Medicine, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
Journal of the American Chemical Society
|October 14, 2014
概括
研究人员设计了对pH值敏感的两,可以自组装成纳米纤维或球体. 这些纳米结构在酸性瘤环境中改变形状,改善药物封装和癌症纳米医学的输送.
科学领域:
- 超分子化学 超分子化学
- 材料科学是一种材料科学.
- 纳米技术纳米技术
背景情况:
- 超分子自我组装可以控制纳米结构形态和对刺激的反应.
- 开发刺激反应系统对于有针对性的药物输送至关重要.
研究的目的:
- 为了设计pH敏感的两 (PAs),以应对瘤微环境,控制纳米结构形状.
- 评估pH诱导的形态转变对药物封装和瘤积累的影响.
主要方法:
- 合成了两种两性质 (PAs),其中包括一个基-基胺H6序列.
- 基于阿里法式尾部放置的纳米纤维或球形基的自我组装被研究.
- 评估了pH值依赖的分解和pH值6.0至6.5.5之间的可逆形态变化.
- 在不同的纳米结构中评估了坎普托他 (CPT) 的封装效率.
- 对pH敏感纳米纤维的定量瘤积累与对照.
主要成果:
- PAs形成了独特的纳米尺度形态 (纳米纤维或球形菌丝),由形尾部位置控制.
- 这两种PA类型都在酸性条件下 (pH 6.0-6.5) 呈现出可逆分解,这是由于histidine的质突.
- 基于H6的纳米纤维实现了高达60%的坎普托西因封装效率,比球形菌丝增加了7倍.
- 对pH敏感的纳米纤维显示,与球形和不改变形态的纳米纤维相比,瘤积累的增强.
结论:
- 由pH值变化引发的超分子纳米结构的形态转换显著影响药物封装和瘤积累.
- 超分子自我组装的分子设计可以调整以增强纳米药物的药理学特性.
- 对于pH值敏感的氨基为开发先进癌症纳米疗法提供了一个有前途的平台.
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