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Updated: Apr 22, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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血清素-2A GPCR中的一个功能选择性机制涉及细胞内循环2的依赖联体的构造

Jose Manuel Perez-Aguilar1, Jufang Shan, Michael V LeVine

  • 1Department of Physiology and Biophysics and §The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University , New York, New York 10065, United States.

Journal of the American Chemical Society
|October 15, 2014
PubMed
概括

分子动力学模拟显示,当与幻觉激素和非幻觉激素激剂结合时,胺2A受体 (5-HT(2A) R的结构变化明显. 这些差异,特别是在细胞内循环2中,可能解释功能选择性和不同的精神活性效应.

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