脱糖酸会影响脂质膜的横向组织
Gemma Moiset1, Cesar A López, Rianne Bartelds
1Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 7, 9747 AG Groningen, The Netherlands.
Journal of the American Chemical Society
|October 16, 2014
概括
诸如砂糖和三糖之类的非降解分糖破坏了膜相分离,形成了均的膜. 这种膜保护能力与这些糖的可访问的结合点有关.
科学领域:
- 生物物理学的生物物理.
- 膜生物学 膜生物学
- 计算生物学 计算生物学
背景情况:
- 脱糖化合物是已知的膜保护.
- 糖和多元组件膜之间的相互作用尚不清楚.
研究的目的:
- 研究单糖和二糖在相分离膜上的影响.
- 阐明非还原性分糖酸对膜组织的影响背后的机制.
主要方法:
- 分子动力学模拟的模拟.
- 光显微镜的光学显微镜.
主要成果:
- 非还原性分糖体 (糖糖,三糖) 破坏了膜相分离的稳定性,导致混合膜.
- 单糖和降解糖不表现出这种作用.
- 非还原性分糖的可访问的界面结合点对于它们对膜的影响至关重要.
结论:
- 非还原性分糖与膜的独特相互作用驱动它们改变横向组织的能力.
- 这种机制解释了糖和三在无水生物保护的生物中的积累.
- 这些发现表明影响膜的表面结合剂的一般机制.
更多相关视频
07:31Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
Published on: September 1, 2023
3.3K
10:15Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
Published on: July 22, 2015
14.4K
相关概念视频
Asymmetric Lipid Bilayer
7.9K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.9K
Membrane Domains
6.1K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
6.1K
Membrane Lipids
19.4K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
19.4K
Membrane Lipids
15.1K
15.1K
Membrane Fluidity
149.7K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
149.7K
Membrane Fluidity
13.8K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
13.8K
