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T-B细胞纠和ICOSL驱动的生殖中心反应中心的前调节

Dan Liu1, Heping Xu1, Changming Shih1

  • 1Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, 100084 Beijing, China.

Nature
|October 16, 2014
PubMed
概括

诱导性T细胞共刺激器连接体 (ICOSL) 驱动生殖中心内的B细胞竞争,促进高亲和度抗体产生细胞的选择. 这种相互作用增强了T-状辅助细胞的参与,这对于长寿的幽默免疫是至关重要的.

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