一个定位的Toll受体代码指导Drosophila中的收延伸
Adam C Paré1, Athea Vichas1, Christopher T Fincher1
1Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.
Nature
|November 4, 2014
概括
果虫中的三个Toll受体协调细胞运动,在发育过程中延长身体轴. 破坏这些受体会损害组织延长,揭示它们在将空间线索与细胞行为联系起来的关键作用.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 收延伸是元动物体轴延长的一个基本过程.
- 有模式的转录因子指导Drosophila发育期间的细胞运动.
- 将转录模式与细胞极性和行为联系在一起的机制仍然不清楚.
研究的目的:
- 为了阐明模式化转录输入如何控制细胞极性和在收延伸期间的行为.
- 为了确定特定的分子参与者在轴延长中调解空间线索.
主要方法:
- 利用Drosophila作为一个模型生物.
- 研究了Toll家族受体 (Toll-2,Toll-6,Toll-8) 的表达模式.
- 评估了破坏Toll受体对细胞极性,结节重塑和轴延长的影响.
主要成果:
- 收费-2,收费-6和收费-8表达为沿前后轴的交叠横线条.
- 这些受体的共同功能是指导平面极性和极化细胞的重新排列.
- 所有三个Toll受体的同时干扰显著减少了由actomyosin驱动的结节重塑和轴延长.
- 托尔受体的子宫外表达可以诱导平面极化actomyosin收缩性.
结论:
- 组织水平的托尔受体表达模式提供了对收延伸至关重要的空间信号.
- 收费受体将前后模式的位置信息与驱动轴延长的细胞行为联系起来.
- 这项研究揭示了Toll家族受体在协调细胞极性和组织形态发生过程中的新角色.
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