皮质杏仁体参与先天的,由气味驱动的行为
Cory M Root1, Christine A Denny2, René Hen3
1Department of Neuroscience and the Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Nature
|November 11, 2014
概括
动物的天生的行为是固定的. 这项研究确定了从嗅球到皮质杏仁核的特定神经回路,这对于先天的气味反应至关重要.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究研究 嗅觉系统研究
- 行为遗传学行为遗传学
背景情况:
- 在天真动物中观察到的先天性行为表明,神经回路是由基因决定的.
- 虽然嗅觉通路已知,但对于先天的嗅觉反应的特定电路仍然未被确定.
研究的目的:
- 为了确定负责天生的嗅觉行为的神经通路.
- 研究皮质杏仁体在处理先天的气味线索中的作用.
主要方法:
- 利用遗传策略来追踪神经回路.
- 在激活的皮质杏仁体神经元中使用弧形基因促进剂来表达通道罗多普辛.
- 使用光学激活来刺激特定的神经元.
主要成果:
- 从嗅球到皮质杏仁核的定型神经回路对于先天的行为至关重要.
- 皮质杏仁核神经元的光学激活成功地引起了先天的气味驱动行为.
- 证实了这种电路对于厌恶和食欲天生的反应的必要性.
结论:
- 皮质杏仁体对于产生先天的,由气味驱动的行为至关重要.
- 这一途径对于先天的嗅觉反应至关重要,独立于先前的学习.
- 这些发现为了解先天的嗅觉处理提供了基础.
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